Speaker: Xingde Li, Professor Department of Biomedical Engineering, John Hopkins University
Abstract: This seminar will focus on our recent progresses on developing high-resolution biophotonic imaging technologies, particularly the second-generation optical coherence tomography (OCT) endoscopy and multiphoton endomicroscopy. These technologies have shown significant translational potential for imaging tissue microanatomies in vivo at a resolution approaching or at standard histopa- thology but without the need for tissue removal, staining or processing. The physics principles, engineering challenges and solutions will be briefly dis- cussed, including the development of advanced lasers, MEMS technology, custom optical fiber, and ultracompact, high-performance imaging optics. Rep- resentative applications of these high-resolution technologies will be presented, including cancer detection, airway physiology imaging, preterm birth risk as- sessment, and intra-operative guidance for neurosurgery. Other potential appli- cations towards basic research such as functional neuroimaging on awake ani- mals will also be discussed.