Dimitris Anastassiou

Charles Batchelor Professor

 
Phone: 212-854-3113
Email: [email protected]
 
Background
Dimitris Anastassiou is Charles Batchelor Professor of Electrical Engineering and Professor of Systems Biology. He is doing research on computational biology with emphasis on biomolecular data mining and analysis of cancer datasets.

Professor Anastassiou joined the E.E. faculty in 1983. From 1979 until 1983 he was a Research Staff member at the IBM Thomas J. Watson Research Center, Yorktown Heights, NY. He is an IEEE Fellow, a Fellow of the National Academy of Inventors, the recipient of an IBM Outstanding Innovation Award, a National Science Foundation Presidential Young Investigator Award, and a Great Teacher Award from the Society of Columbia Graduates. His previous research was in the area of video technology. He is author of patents accepted as essential for the implementation of the international standards MPEG-2, AVC/H.264 and MVC used in digital television storage, transmission and broadcasting.

His research in systems biology is focused on the discovery and elucidation of biomolecular mechanisms in cancer and the associated diagnostic, prognostic and therapeutic applications in personalized medicine.  
 
 
In the News
 
 
Education

• 1979 Ph.D., University of California, Berkeley
• 1975 M.S., University of California, Berkeley
• 1974 B.S., National Technical University of Athens, Greece

• L. Cai, M. Kolonin and D. Anastassiou, "The fibro-adipogenic progenitor APOD+DCN+LUM+ cell population in aggressive carcinomas," Cancer and Metastasis Reviews, Vol. 43, Issue 3, pp. 977-980, September 2024.
• A. Salcedo,... D. Anastassiou ... P. Boutros, "Crowd-sourced benchmarking of single-sample tumour subclonal reconstruction," Nature Biotechnology, https://doi.org/10.1038/s41587-024-02250-y. Online ahead of print, June 2024.
• L. Cai and D. Anastassiou, "CASCC: A co-expression assisted single-cell RNA-seq data clustering method," Bioinformatics. Vol. 40, Issue 5, btae283, May 2024.
• M. Kolonin and D. Anastassiou, "Adipose stromal cell-derived cancer-associated fibroblasts suppress FGFR inhibitor efficacy," Cancer Research, In the Spotlight - Invited, Vol. 84, Issue 5, pp. 648-649, March 2024.
• O.E. Ogundijo, K. Zhu, X. Wang and D. Anastassiou, "Characterizing intra-tumor heterogeneity from somatic mutations without copy-neutral assumption," IEEE/ACM Transactions on Computational Biology and Bioinformatics, Vol. 18, Issue 6, pp. 2271-2280, Nov-Dec 2021.
• K. Zhu, L. Cai, C. Cui and D. Anastassiou, "Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts," PLOS Computational Biology, 17(7): e1009228, July 2021.
• K. Zhu and D. Anastassiou, "2DImpute: Imputation in Single Cell RNA-Seq Data from Correlations in Two Dimensions," Bioinformatics, Vol. 36, Issue 11, pp. 3588-3589, June 2020.
• A. Salcedo, ... D. Anastassiou ... P. Boutros, "A community effort to create standards for evaluating tumor subclonal reconstruction," Nature Biotechnology, Vol. 38, pp. 97-107, January 2020.
• K. Zhu, T.H. Ou Yang, V. Dorie, T. Zheng and D. Anastassiou, "Meta-analysis of expression and methylation signatures indicates a stress-related epigenetic mechanism in multiple neuropsychiatric disorders," Translational Psychiatry, Vol. 9, No. 32, January 2019.
• V. Thorsson et al, "The Immune Landscape of Cancer," Immunity, Vol. 48, Issue 4, pp. 812-830, April 2018.
• D. Anastassiou, "Comment on A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets," Cancer Letters, Vol. 393, pp. 125-126, May 2017.
• C.P. Miller, J.D. Thorpe, A.N. Kortum, C.M. Coy, W.Y. Cheng, T.S. Ou Yang, D. Anastassiou, J. D. Beatty, N.D. Urban and C.A. Blau, "JAK2 Expression is Associated with Tumor-Infiltrating Lymphocytes and Improved Breast Cancer Outcomes: Implications for Evaluating JAK2 Inhibitors," Cancer Immunology Research, Vol 2, Issue 4, pp. 301-6, April 2014.
• W.Y. Cheng, T.H. Ou Yang and D. Anastassiou, "Development of a prognostic model for breast cancer survival in an open challenge environment," Science Translational Medicine, Vol. 5, Issue 181, p. 181ra50, April 2013. This research article describes the winning model of the Sage Bionetworks/DREAM Breast Cancer Prognosis Challenge, which is the cover story of the journal. The winning model is also featured as a Research Highlight in Nature Reviews Cancer, Vol. 13, Issue 6, p. 378, June 2013.
• W.Y. Cheng, T.H. Ou Yang and D. Anastassiou, "Biomolecular events in cancer revealed by attractor metagenes," PLOS Computational Biology, Vol. 9, Issue 2, February 2013.
• Y.H. Cheung, J. Watkinson and D. Anastassiou, "Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC," Human Genetics, Vol. 129, No. 2, pp. 161-176, February 2011.
• H. Kim, J. Watkinson, V. Varadan and D. Anastassiou, "Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1," BMC Medical Genomics, Vol. 3, Issue 51, November 2010. [Highly accessed]
• J. Watkinson and D. Anastassiou, "Synergy Disequilibrium Plots: graphical visualization of pairwise synergies and redundancies of SNPs with respect to a phenotype" Bioinformatics, Vol. 5, No. 11, pp. 1445-1446, June 2009.
• K.C. Liang, X. Wang and D. Anastassiou, "A Profile-Based Deterministic Sequential Monte Carlo Algorithm for Motif Discovery," Bioinformatics, Vol. 24, Issue 1, January 2008, pp. 46-55.
• D. Anastassiou, "Computational Analysis of the Synergy Among Multiple Interacting Genes," Molecular Systems Biology, Vol. 3, No. 83, February 2007.
• D. Anastassiou, H. Liu and V. Varadan, "Variable Window Binding for Mutually Exclusive Alternative Splicing," Genome Biology, Vol. 7, Issue 1, pp. R2.1-R2.12, January 2006. [Highly accessed]
• D. Anastassiou, "Genomic Signal Processing," IEEE Signal Processing Magazine, theme article, Vol. 18, No 4, pp. 8-20, July 2001.

Department of Electrical Engineering, 1328 S.W. Mudd 500 West 120th Street, New York, NY 10027 Phone: (212) 854-3105 Fax: (212) 932-9421