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Dimitris Anastassiou

Professor

Phone: 212-854-3113
Fax: 201-567-0799
Email: anastas@ee.columbia.edu

 

Background

Dimitris Anastassiou is Professor and Director of Columbia University's Genomic Information Systems Laboratory, and a member of Columbia's Center for Computational Biology and Bioinformatics. His research is focused on computational biology with emphasis on systems-based gene expression data analysis and comparative genomics.

 

Professor Anastassiou joined the E.E. faculty in 1983. From 1979 until 1983, he was a Research Staff member at the IBM Thomas J. Watson Research Center, Yorktown Heights, NY. He is an IEEE Fellow, the recipient of an IBM Outstanding Innovation Award, a National Science Foundation Presidential Young Investigator Award, and a Columbia University Great Teacher Award. His previous research interests have been in the areas of information theory and signal processing with contributions to the international digital television coding standard, MPEG-2.

 

Education

o                    1979 Ph.D., University of California, Berkeley

o                    1975 M.S., University of California, Berkeley

o                    1974 Diploma, National Technical University of Athens, Greece

 

Selected Recent Publications

·                     J. Watkinson, K.C. Liang, X. Wang, T. Zheng and D. Anastassiou, "Inference of regulatory gene interactions from expression data using three-way mutual information," Annals of the New York Academy of Sciences, invited paper as best performer in a DREAM2 network inference challenge, in press, 2008.

·                     K.C. Liang, X. Wang and D. Anastassiou, "A sequential Monte Carlo Method for Motif Discovery," IEEE Transactions on Signal Processing, Vol. 56, No. 9, September 2008, pp. 4496-4507.

·                     J. Watkinson, X. Wang, T. Zheng and D. Anastassiou, "Identification of gene interactions associated with disease from gene expression data using synergy networks,," BMC Systems Biology, Vol. 2, Issue 10, February 2008. [Highly accessed]

·                     K.C. Liang, X. Wang and D. Anastassiou, "A Profile-Based Deterministic Sequential Monte Carlo Algorithm for Motif Discovery," Bioinformatics, Vol. 24, Issue 1, January 2008, pp. 46-55.

·                     K.C. Liang, X. Wang and D. Anastassiou, "Bayesian basecalling for DNA sequence analysis using hidden Markov models," ACM/IEEE Transactions on Computational Biology and Bioinformatics, Vol. 4, No. 3, July-September 2007, pp. 430-440.

·                     D. Anastassiou, "Computational Analysis of the Synergy Among Multiple Interacting Genes" (Review Article), Molecular Systems Biology, Vol. 3, No. 83, February 2007.

·                     V. Varadan, D. Miller III and D. Anastassiou, "Computational Inference of the Molecular Logic for Synaptic Connectivity in C. elegans," Bioinformatics, Vol. 22, Issue 14 – ISMB 2006, pp. e497-e506, July 2006.

·                     V. Varadan and D. Anastassiou, "Inference of Disease-Related Molecular Logic from Systems-Based Microarray Analysis," PLoS Computational Biology, Vol. 2, Issue 6, June 2006, pp. 585-597.

·                     D. Anastassiou, H. Liu and V. Varadan, "Variable Window Binding for Mutually Exclusive Alternative Splicing," Genome Biology, Vol. 7, Issue 1, pp. R2.1-R2.12, January 2006. [Highly accessed]

·                     G. Cavelier and D. Anastassiou, "Phenotype Analysis Using Network Motifs Derived from Changes in Regulatory Network Dynamics," Proteins, Vol. 60, Issue 3, pp. 525-546, 2005.

·                     X. Wang, D. Anastassiou and D. Guo, "Statistical Inference of Transcriptional Regulatory Networks," in Genomic Signal Processing and Statistics, E. Dougherty et al. (Ed.), Hindawi Pub., New York, 2005.

·                     D. Sussillo, A. Kundaje and D. Anastassiou, "Spectrogram Analysis of Genomes*," EURASIP Journal on Applied Signal Processing, special issue on Genomic Signal Processing, Vol. 2004, No. 1, Jan. 2004, pp. 29-42.

·                     G. Cavelier and D. Anastassiou, "Data-Based Model and Parameter Evaluation in Dynamic Transcriptional Regulatory Networks," Proteins, Vol. 55, Issue 2, pp. 339-350, 2004.

·                     D. Anastassiou, "Genomic Signal Processing," IEEE Signal Processing Magazine theme article, vol. 18, No 4, July 2001, pp. 8-20.

·                     D. Anastassiou, "Frequency-Domain Analysis of Biomolecular Sequences," Bioinformatics, vol. 16, no. 12, December 2000, pp. 1073-1081.

 

Some publications from previous lifetime

 

*Download SpectroFish, a software tool producing spectrograms for visualizing periodicity and relative nucleotide content in DNA.

 

Department of Electrical Engineering, 1328 S.W. Mudd
500 West 120th Street, New York, NY 10027
Phone: (212) 854-3105 Fax: (212) 932-9421