Large-scale neural interface devices

Date: 10:00am, April 4, 2016
Location: Costa Commons, CEPSR 750
Speaker:   Dion Khodagholy is a fellow at the Simon’s Society of Fellows and a postdoctoral research associate in Prof. György Buzsáki’s laboratory at New York University Langone Medical Center

Abstract: As our understanding of the brain’s physiology and pathology progresses, increasingly sophisticated technologies are required to advance discoveries in neuroscience and develop more effective approaches to treating brain disease. There is a tremendous need for advanced materials solutions at the biotic/abiotic interface to improve the spatiotemporal resolution of neuronal recording. Organic electronic devices offer a unique approach to these challenges, due to their mixed ionic/electronic conduction, mechanical flexibility, enhanced biocompatibility, and capability for drug delivery. We designed, developed, and characterized conformable organic electronic devices in the form of transistors and electrodes to efficiently interface with the brain and acquire neurophysiological activity not previously accessible with recordings from the brain surface. These devices have facilitated large-scale rodent neurophysiology experiments and uncovered a novel hippocampal-cortical oscillatory interaction. The biocompatibility of the devices allowed intra-operative recording from patients undergoing epilepsy surgery, highlighting the translational capacity of this class of neural interface devices. In parallel, we are developing the high-speed electronics and embedded acquisition and storage systems required to make high channel count, chronic neurophysiological recording from animals and human subjects possible. This multidisciplinary approach will enable the development of new devices based on organic electronics, with broad applicability to the understanding of physiologic and pathologic network activity, control of brain-machine interfaces, and therapeutic closed-loop devices.

Biography:   Dion Khodagholy is a fellow at the Simon’s Society of Fellows and a postdoctoral research associate in Prof. György Buzsáki’s laboratory at New York University Langone Medical Center. He received his Master’s degree from the University of Birmingham (UK) in Electronic Engineering. This was followed by a second Master’s degree in Microelectronics at the Ecole des Mines combined with industry experience at ST Microelectronics. He attained his Ph.D. degree in Microelectronics at the Department of Bioelectronics (BEL) of the Ecole des Mines (France) with Prof. George Malliaras. At BEL, he focused on understanding organic semiconductor device physics and developing organic-based devices to interface with biology. His postdoctoral research at NYULMC is focused on three main domains: (i) design and development of large-scale, organic material-based neural interface devices; (ii) analysis of neural data acquired by these devices to understand large-scale neural network function; (iii) translation of these advancements to neural data acquisition in patients with epilepsy. His research explores the interface of electronics and the brain in the context of both applied and discovery sciences, with the ultimate goal of innovating in device engineering and neuroscience methods to improve diagnosis and treatment of neuropsychiatric disease.

 

 
Hosted by Professor  Nima Mesgarani


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